Hi Martin, I have no definitive answer but I'm in interested in others opinions also as I am also looking at a 376 for extended shorthanded BW cruising. I've not heard anything bad said about the boat as long as you get a well maintained one. All of my investigations lead me to believe it's a strong comfortable boat which would suit my purposes perfectly in terms of VFM vs capability.
That said, I've been watching a lot of YT videos of other people doing long distance sailing and they are doing it in all sorts of vessels from rowing boats to superyachts, so as long as you have some skills, keep a weather eye out and know the boat inside out then I guess it would be ok.
I'll keep an eye on your thread to see if any more experienced owners can offer any advice.